H2N2V1, Main, Exploration, bibRecord, 002955

Antigenic memory to influenza A viruses in man determined by monovalent vaccines.

Identifieur interne : 002955 ( Main/Exploration ); précédent : 002954; suivant : 002956

Antigenic memory to influenza A viruses in man determined by monovalent vaccines.

Auteurs : W. M. Marine ; J. E. Thomas

Source :

Postgraduate Medical Journal [ 0032-5473 ] ; 1979-02.

RBID : ISTEX:D6BDADF3B146BA88B0B187EBB9944D1C29ADA9A4

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (biosynthèse), Antigènes viraux (immunologie), Enfant, Facteurs de l'âge, Grippe humaine (immunologie), Humains, Hémagglutinines virales (immunologie), Mémoire immunologique, Sujet âgé, Vaccins antigrippaux (immunologie), Virus de la grippe A (immunologie).
MESH :
- biosynthèse : Anticorps antiviraux.
- immunologie : Antigènes viraux, Grippe humaine, Hémagglutinines virales, Vaccins antigrippaux, Virus de la grippe A.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Facteurs de l'âge, Humains, Mémoire immunologique, Sujet âgé.

English descriptors

KwdEn :
- Adolescent, Adult, Age Factors, Aged, Antibodies, Viral (biosynthesis), Antigens, Viral (immunology), Child, Hemagglutinins, Viral (immunology), Humans, Immunologic Memory, Influenza A virus (immunology), Influenza Vaccines (immunology), Influenza, Human (immunology), Middle Aged.
MESH :
- chemical , biosynthesis : Antibodies, Viral.
- chemical , immunology : Antigens, Viral, Hemagglutinins, Viral, Influenza Vaccines.
- immunology : Influenza A virus, Influenza, Human.
Teeft :
- Adolescent, Adult, Age Factors, Aged, American journal, American physicians, Anamnestic, Anamnestic response, Anamnestic responses, Anamnestic responsiveness, Antibody, Antibody absorption studies, Antibody profile, Antibody removal, Antibody response, Antibody units, Antigenic, Antigenic memory, Chick cell, Child, Cohort, Cohort volunteers, Dowdle, Experimental medicine, Haemagglutinin, Haemagglutinin relationship, Haemagglutinin relationships, Haemagglutininspecific recombinants, Hennessy, Heterologous, Hon1, Hon1 vaccines, Hong kong, Hong kong influenza, Human influenza, Human sera, Humans, Immunization, Immunization studies, Immunologic Memory, Infectious diseases, Influenza, Initial influenza, Internal medicine, Major groups, Masurel, Middle Aged, Monovalent, More antibody units, Original antigenic, Original antigenic sins, Pandemic, Present study, Preventive medicine, Public health service, Recombinant, Recycling, Serologic recapitulation, Subsequent influenza, Swine influenza, Swine influenza virus, Vaccine, Vaccine study.

Abstract

This study was conducted to test the limits of the doctrine of 'original antigenic sin' in influenza A. The design included use of zonal purified 1000 CCA (chick cell agglutinating) units monovalent vaccines consisting of H0N1, H1N1, H2N2 and H3N2. Age cohorts with different primary influenza A infections were established for the 687 volunteers. The vaccines administered to each age cohort were selected to test the responsiveness of original antigenic sin antibody to homologous and heterologous challenge. Anamnestic responses were demonstrated with Hsw1n1,H0N1, and H1N1 and with H2N2 and H3N2 but not between the groups. The synthesis of these findings is that there are 2 original antigenic sins - 2 families of influenza A viruses.

Url:

DOI: 10.1136/pgmj.55.640.98

Affiliations:

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<term>Antigens, Viral (immunology)</term>
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<term>Hemagglutinins, Viral (immunology)</term>
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<term>Antigènes viraux (immunologie)</term>
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<front><div type="abstract" xml:lang="en">This study was conducted to test the limits of the doctrine of 'original antigenic sin' in influenza A. The design included use of zonal purified 1000 CCA (chick cell agglutinating) units monovalent vaccines consisting of H0N1, H1N1, H2N2 and H3N2. Age cohorts with different primary influenza A infections were established for the 687 volunteers. The vaccines administered to each age cohort were selected to test the responsiveness of original antigenic sin antibody to homologous and heterologous challenge. Anamnestic responses were demonstrated with Hsw1n1,H0N1, and H1N1 and with H2N2 and H3N2 but not between the groups. The synthesis of these findings is that there are 2 original antigenic sins - 2 families of influenza A viruses.</div>
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Antigenic memory to influenza A viruses in man determined by monovalent vaccines.

Antigenic memory to influenza A viruses in man determined by monovalent vaccines.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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